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I don't brew without Wyeast Yeast Nutrient. It does what it says it does. I use it in every boil and when making big yeast starters for lagers and high gravity ales. It costs pennies per batch and helps keep your yeast happy. Along with a starter and injection of pure 02 I usually see airlock activity in 4-6 hours. There are other yeast nutrients out there and they probably work just fine. I've had great results with Wyeast.